Sensitization with Eustrongylides sp. (Nematoda: Dioctophymatidae) antigens

Sensitization with Eustrongylides sp. (Nematoda: Dioctophymatidae) antigens induce manufacturing of particular IgG and IgE in murine mannequin 

Fish consumption performs an necessary position in human eating regimen. Hoplias malabaricus, generally often known as traíra, is a freshwater fish extensively appreciated in a number of Brazilian states and regularly contaminated by Eustrongylides sp. fourth-instar larvae (L4). The purpose of the current research was to guage allergenic potential of Eustrongylides sp. L4 crude extract (CEE). BALB/c mice had been immunized intraperitoneally (IP) by 10 μg CEE with 2 mg of aluminum hydroxide on days zero and 35. Particular IgG and IgE antibody ranges had been decided after immunization and mobile immunity was evaluated by assessing intradermal response in ear pavilion.

Epicutaneous sensitization was carried out in dorsal area by antigen publicity utilizing a Finn-type chamber containing 50 μg of CEE or saline answer, adopted by analysis of particular antibody ranges. IP immunization resulted in a gradual enhance in IgG antibody ranges and transitory IgE manufacturing. Vital enhance in ear thickness was noticed in mobile hypersensitivity response. In case of antigen publicity by epicutaneous route, CEE was in a position to induce meaningfully elevated ranges of particular IgG and IgE antibodies in addition to heightened mobile immunity. Each intraperitoneal immunization and epicutaneous contact with Eustrongylides sp. larval antigens had been noticed for first time to be able to inducing immunological sensitization in mice.

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Scl-70 Antigen

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EUR 5580

Cow Scl-70 Antigen

abx069937-10g 10 g Ask for price

Cow Scl-70 Antigen

abx069937-5g 5 g
EUR 1750

Rabbit Scl-70 Antigen

abx069936-25g 25 g
EUR 1862.5

Scl-70 Antigen Antibody

abx022697-2ml 2 ml
EUR 594

Scl-70 Antigen Antibody

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Scl-70 Antigen Antibody

abx022697-80l 80 µl
EUR 575

Scl-70 Antigen Protein

abx069936-1000Units 1000 Units
EUR 1846.8

Scl-70 Antigen Protein

abx069937-02mg 0.2 mg
EUR 1296

OPMA04225-200UG - Scl-70 Antigen Protein

OPMA04225-200UG 0.2MG
EUR 1399

OPEF01639-1MG - Recombinant SCL-70 Antigen

OPEF01639-1MG 1mg
EUR 1683

Borrelia Afzelii Antigen

NAT41583-100 0.1
EUR 391.66
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Afzelii Antigen

NAT41583-500 0.5
EUR 1176.24
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Garinii Antigen

NAT41584-100 0.1
EUR 391.66
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Borrelia Garinii Antigen

NAT41584-500 0.5
EUR 1176.24
Description: Harvested bacteria are washed and detergent solubilized to produce a cytoplasmic extract enriched with lipoproteins and outer surface proteins (OSPs). The antigen is presented in phosphate buffered saline containing 1 % n-octyl-β-D-glucopyranoside.

Brucella Abortus Antigen

NAT41599-100 0.1
EUR 391.66
Description: Brucella abortus lysate, produced by fermentation.

Brucella Abortus Antigen

NAT41599-500 0.5
EUR 1176.24
Description: Brucella abortus lysate, produced by fermentation.

Candida Albicans Antigen

NAT41601-100 0.1
EUR 391.66
Description: Candida albicans is grown on solid medium, washed, disrupted and subjected to an extraction process. The antigen consists of cytoplasmic and cell wall components.

Candida Albicans Antigen

NAT41601-500 0.5
EUR 1176.24
Description: Candida albicans is grown on solid medium, washed, disrupted and subjected to an extraction process. The antigen consists of cytoplasmic and cell wall components.

Canine Parvovirus Antigen

NAT41594-100 0.1
EUR 391.66
Description: Canine Parvovirus, produced in CRFK cells.

Canine Coronavirus Antigen

NAT41590-100 0.1
EUR 391.66
Description: Canine Coronavirus produced in A-72 cells.

Feline Calicivirus Antigen

NAT41595-100 0.1
EUR 391.66
Description: Feline Calicivirus produced in FC 3TG cells.

Scl-70

GWB-E5CE57 0.2 mg Ask for price

Scl-70

MBS634416-1000Units 1000Units
EUR 1735

Scl-70

MBS634416-5x1000Units 5x1000Units
EUR 7580

Helicobacter Pylori Antigen

NAT41603-100 0.1
EUR 391.66
Description: Bacteria are cultured on solid medium, harvested, washed and solubilised. The antigen is partially purified by detergent extraction and centrifugation.

Helicobacter Pylori Antigen

NAT41603-500 0.5
EUR 1176.24
Description: Bacteria are cultured on solid medium, harvested, washed and solubilised. The antigen is partially purified by detergent extraction and centrifugation.

Campylobacter Jejuni Antigen

NAT41600-100 0.1
EUR 391.66
Description: Campylobacter jejuni is cultured on solid medium. This antigen is a partially purified detergent extract of the membrane fraction. The main component is an outer membrane protein, approximately 45 kDa in SDS-PAGE.

Campylobacter Jejuni Antigen

NAT41600-500 0.5
EUR 1176.24
Description: Campylobacter jejuni is cultured on solid medium. This antigen is a partially purified detergent extract of the membrane fraction. The main component is an outer membrane protein, approximately 45 kDa in SDS-PAGE.

Chlamydia Trachomatis Antigen

CT022-1000 1.0
EUR 378.9
Description: Chlamydia trachomatis antigens from clarified cell lysate.

Neisseria Gonorrhoeae Antigen

NG01-1000 1.0
EUR 378.9
Description: Homogenised lysate of pure bacteria.

Mycoplasma Pneumoniae Antigen

MP901-1000 1.0
EUR 1010.39
Description: Mycoplasma pneumoniae whole organisms that have been purified and detergent treated to enrich antigenic proteins and decrease background.

Mycoplasma Pneumoniae Antigen

MP901-200 0.2
EUR 270.46
Description: Mycoplasma pneumoniae whole organisms that have been purified and detergent treated to enrich antigenic proteins and decrease background.

Echovirus Antigen, Recombinant

REC31776-100 0.1
EUR 276.84
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus

Echovirus Antigen, Recombinant

REC31776-500 0.5
EUR 1043.56
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus

Trichomonas Vaginalis Antigen

TV01-1000 1.0
EUR 421
Description: Washed & lysed suspension of whole protozoa

Scl-70 Antibody

GWB-D82F78 2 ml Ask for price

Echinococcus Granulosus Antigen

NAT41602-100 0.1
EUR 391.66
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid.

Echinococcus Granulosus Antigen

NAT41602-500 0.5
EUR 1176.24
Description: Echinococcus granulosus material is derived from bovine hydatid cyst as sterile filtered cyst fluid.

Enterovirus Antigen, Recombinant

REC31772-100 0.1
EUR 276.84
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus IgA, IgG and IgM ELISA.

Enterovirus Antigen, Recombinant

REC31772-500 0.5
EUR 1043.56
Description: Proprietary recombinant antigen expressed in E. coli and purified by chromatography. Individually pooled antigens shown to react with QC serum panel (multiple negative, borderline and positive sera) within defined reactivity range in Coxsackie-/Echovirus IgA, IgG and IgM ELISA.

Cytomegalovirus Purified Antigen

CMV-HP-100 0.1
EUR 318.94
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Cytomegalovirus Purified Antigen

CMV-HP-1000 1.0
EUR 2096.06
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Cytomegalovirus Purified Antigen

CMV-HP-500 0.5
EUR 1279.58
Description: A concentrated source of human Cytomegalovirus particles purified by sucrose gradient ultracentrifugation.

Astrovirus Antigen (Type 1)

AS02-1000 1.0
EUR 1654.65
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells.

Astrovirus Antigen (Type 1)

AS02-200 0.2
EUR 442.69
Description: A concentrated source of Astrovirus particles and Astrovirus proteins from a lysate of host cells.

Yersinia pestis V antigen

REC32028-100 0.1
EUR 491.53
Description: Yersinia pestis V antigen (LcrV antigen, capsule protein fraction 1, type III secretion system needle tip protein). The protein is produced as an N-terminal GST fusion, with GST being cleaved by thrombin and is not present in the final product.

Yersinia pestis V antigen

REC32028-500 0.5
EUR 2421.37
Description: Yersinia pestis V antigen (LcrV antigen, capsule protein fraction 1, type III secretion system needle tip protein). The protein is produced as an N-terminal GST fusion, with GST being cleaved by thrombin and is not present in the final product.

Canine Herpes Virus Antigen

NAT41592-100 0.1
EUR 391.66
Description: Canine Herpes virus, produced in MDCK cells.

Canine Adenovirus 1 Antigen

NAT41587-100 0.1
EUR 391.66
Description: Canine Adenovirus Type 1, produced in A-72 cells.

Canine Adenovirus 2 Antigen

NAT41588-100 0.1
EUR 391.66
Description: Canine Adenovirus Type 2, produced in A-72 cells.

Canine Distemper Virus Antigen

NAT41591-100 0.1
EUR 391.66
Description: Canine Distemper virus, produced in SL-29 cells.

Canine Parainfluenza Virus Antigen

NAT41593-100 0.1
EUR 391.66
Description: Canine Parainfluenza virus antigen, produced in MDCK cells.

Feline Panleukopenia Virus Antigen

NAT41597-100 0.1
EUR 391.66
Description: Feline Panleukopenia Virus (FPLV; feline parvovirus) antigen, produced in CRFK cells.

Norovirus GII.4 VP1 Antigen

REC31620-100 0.1
EUR 302.36
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

Norovirus GII.4 VP1 Antigen

REC31620-1000 1.0
EUR 1830.71
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

Norovirus GII.4 VP1 Antigen

REC31620-500 0.5
EUR 1066.53
Description: Recombinant Norovirus GII.4 VP1 antigen produced in 293 human cells.

Cytomegalovirus Cell Lysate Antigen

CMV-CL-100 0.1
EUR 223.26
Description: A clarified cell lysate containing a mix of CMV antigens from all stages of the replication life cycle.

Cytomegalovirus Cell Lysate Antigen

CMV-CL-1000 1.0
EUR 1422.47
Description: A clarified cell lysate containing a mix of CMV antigens from all stages of the replication life cycle.

Feline Viral Rhinotracheitis Antigen

NAT41598-100 0.1
EUR 391.66
Description: Feline Viral Rhinotracheitis (FVR; feline herpes virus, FHV-1) antigen, produced in CRFK cells.

Herpes Simplex Virus 1 Antigen

HS105-1000 1.0
EUR 1178.79
Description: HSV-1 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Herpes Simplex Virus 1 Antigen

HS105-200 0.2
EUR 294.7
Description: HSV-1 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Herpes Simplex Virus 2 Antigen

HS205-1000 1.0
EUR 1178.79
Description: HSV-2 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Herpes Simplex Virus 2 Antigen

HS205-200 0.2
EUR 294.7
Description: HSV-2 particles from a cell lysate are purified by sucrose gradient ultracentrifugation.

Ross River Virus Recombinant Antigen

REC31969-100 0.1
EUR 757.8
Description: Recombinant Ross River virus antigen expressed in HEK293 cells as virus-like particles and purified by sucrose density gradients and precipitation. Virus-like particles were then solubilized in PBS containing 0.2% SDS to prevent aggregation of particles. The preparation is not particulate. Antigens in the preparation include Envelope proteins 1 and 2 and Nucleoprotein.

Ross River Virus Recombinant Antigen

REC31969-500 0.5
EUR 2844.92
Description: Recombinant Ross River virus antigen expressed in HEK293 cells as virus-like particles and purified by sucrose density gradients and precipitation. Virus-like particles were then solubilized in PBS containing 0.2% SDS to prevent aggregation of particles. The preparation is not particulate. Antigens in the preparation include Envelope proteins 1 and 2 and Nucleoprotein.

Canine Adenovirus 1 and 2 Antigen

NAT41589-100 0.1
EUR 391.66
Description: A mixture of Canine Adenovirus Type 1 and Type 2, produced in A-72 cells.

Hepatitis B Virus E Antigen (HBeAg)

REC31677-100 0.1
EUR 456.72
Description: Recombinant Hepititis B Virus E Protein (HBeAg).

Hepatitis B Virus E Antigen (HBeAg)

REC31677-500 0.5
EUR 1941.06
Description: Recombinant Hepititis B Virus E Protein (HBeAg).

Hepatitis B Virus Core Antigen (HBcAg)

REC31689-100 0.1
EUR 456.72
Description: Recombinant Hepititis B Virus Core Protein (HBcAg).

Hepatitis B Virus Core Antigen (HBcAg)

REC31689-500 0.5
EUR 1370.16
Description: Recombinant Hepititis B Virus Core Protein (HBcAg).

Hepatitis C Virus Core Antigen (HCcAg)

REC31693-100 0.1
EUR 484.79
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.

Hepatitis C Virus Core Antigen (HCcAg)

REC31693-500 0.5
EUR 1455.64
Description: Recombinant Hepatitis C Virus core protein is produced in E. coli and fused with a His-tag.

Feline Infectious Peritonitis Virus Antigen

NAT41596-100 0.1
EUR 391.66
Description: Feline Infectious Peritonitis virus (FIPV; feline coronavirus) antigen, produced in CRFK cells.

Herpes Simplex Virus 1 Lysate Antigen

HS104-1000 1.0
EUR 270.46
Description: A high concentration of HSV-1 particles and proteins from a clarified cell lysate.

Herpes Simplex Virus 2 Lysate Antigen

HS204-1000 1.0
EUR 270.46
Description: A high concentration of HSV-2 particles and proteins from a clarified cell lysate.

Legionella pneumophila antigen (native extract)

NAT41580-100 0.1
EUR 391.66
Description: Inactivated Legionella pneumophila antigen from culture.

Streptococcus Pneumoniae Antigen, Native Extract

NAT41604-100 0.1
EUR 391.66
Description: Inactivated Streptococcus pneumoniae antigen from culture.

Leptospira Biflexa Antigen (Strain Patoc 1)

NAT41582-100 0.1
EUR 391.66
Description: Inactivated Leptospira biflexa antigen (Strain Patoc 1) from broth culture.

Leptospira Biflexa Antigen (Strain Patoc 1)

NAT41582-500 0.5
EUR 1176.24
Description: Inactivated Leptospira biflexa antigen (Strain Patoc 1) from broth culture.

Scl-70 Ab

DE7510 96
EUR 111

Scl-70 ELISA

E22-HC9088 96T
EUR 495

Scl-70 ELISA

GWB-BQK162 96 Well Plate Ask for price

Scl-70 ELISA

MBS8579308-5x96Tests 5x96Tests
EUR 2735

Scl-70 ELISA

MBS8579308-96Tests 96Tests
EUR 595

Mouse Anti-Hepatitis B Surface Antigen Antibody (1834)

MAB12230-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Hepatitis B virus surface antigen (1834).

Mouse Anti-Hepatitis B Surface Antigen Antibody (1837)

MAB12231-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Hepatitis B virus surface antigen (1837)

Mouse Anti-Hepatitis B Surface Antigen Antibody (1838)

MAB12232-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Hepatitis B virus surface antigen (1838)

Mouse Anti-Hepatitis B Virus E Antigen Antibody (1892)

MAB12226-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (1892)

Mouse Anti-Hepatitis B Virus E Antigen Antibody (1893)

MAB12227-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (1893)

Mouse Anti-Hepatitis B Virus E Antigen Antibody (1894)

MAB12228-100 0.1
EUR 275.56
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (1894)

Mouse Anti-Hepatitis B Virus E Antigen Antibody (M132)

MAB12298-100 0.1
EUR 276.84
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (M132)

Mouse Anti-Hepatitis B Virus E Antigen Antibody (M132)

MAB12298-500 0.5
EUR 695.29
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (M132)

Mouse Anti-Hepatitis B Virus E Antigen Antibody (M133)

MAB12299-100 0.1
EUR 276.84
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (M133)

Mouse Anti-Hepatitis B Virus E Antigen Antibody (M133)

MAB12299-500 0.5
EUR 695.29
Description: Mouse monoclonal antibody specific for Hepatitis B virus e antigen (M133)

Zika Virus Envelope Protein, Suriname Strain (SCL)

REC31998-100 0.1
EUR 723.36
Description: Recombinant Zika virus envelope protein expressed in HEK293 mammalian cells, with C terminal 6-His tag.

Zika Virus Envelope Protein, Suriname Strain (SCL)

REC31998-250 0.25
EUR 1491.36
Description: Recombinant Zika virus envelope protein expressed in HEK293 mammalian cells, with C terminal 6-His tag.

Yersinia pestis chain B F1 capsule antigen, C-terminal His-tag

REC32027-100 0.1
EUR 491.53
Description: Yersinia pestis chain B F1 capsule antigen (Antig_Caf1)

Yersinia pestis chain B F1 capsule antigen, C-terminal His-tag

REC32027-500 0.5
EUR 2421.37
Description: Yersinia pestis chain B F1 capsule antigen (Antig_Caf1)

Scl-70 ELISA Kit

MBS580083-5x96StripWells 5x96-Strip-Wells
EUR 1150

Scl-70 ELISA Kit

MBS580083-96StripWells 96-Strip-Wells
EUR 265

Cat Scl-70 Antibody ELISA Kit

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Rat Scl-70 Antibody ELISA Kit

MBS046525-10x96StripWells 10x96-Strip-Wells
EUR 6725

Rat Scl-70 Antibody ELISA Kit

MBS046525-48StripWells 48-Strip-Wells
EUR 550

Rat Scl-70 Antibody ELISA Kit

MBS046525-5x96StripWells 5x96-Strip-Wells
EUR 3420

Rat Scl-70 Antibody ELISA Kit

MBS046525-96StripWells 96-Strip-Wells
EUR 765

Rat Scl-70 Antibody ELISA Kit

MBS733766-10x96StripWells 10x96-Strip-Wells
EUR 5685

Rat Scl-70 Antibody ELISA Kit

MBS733766-48StripWells 48-Strip-Wells
EUR 485

Rat Scl-70 Antibody ELISA Kit

MBS733766-5x96StripWells 5x96-Strip-Wells
EUR 3020

Rat Scl-70 Antibody ELISA Kit

MBS733766-96StripWells 96-Strip-Wells
EUR 690

Goat Scl-70 Antibody ELISA Kit

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Duck Scl-70 Antibody ELISA Kit

MBS064027-INQUIRE INQUIRE Ask for price

Fish Scl-70 Antibody ELISA Kit

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Cavy Scl-70 Antibody ELISA Kit

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Goat Scl-70 Antibody ELISA Kit

MBS745982-10x96StripWells 10x96-Strip-Wells
EUR 5685

Goat Scl-70 Antibody ELISA Kit

MBS745982-48StripWells 48-Strip-Wells
EUR 485

Goat Scl-70 Antibody ELISA Kit

MBS745982-5x96StripWells 5x96-Strip-Wells
EUR 3020

Goat Scl-70 Antibody ELISA Kit

MBS745982-96StripWells 96-Strip-Wells
EUR 690

Human Scl-70 Antibody ELISA Kit

MBS021013-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Scl-70 Antibody ELISA Kit

MBS021013-48StripWells 48-Strip-Wells
EUR 550

Human Scl-70 Antibody ELISA Kit

MBS021013-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Scl-70 Antibody ELISA Kit

MBS021013-96StripWells 96-Strip-Wells
EUR 765

Sheep Scl-70 Antibody ELISA Kit

MBS035116-10x96StripWells 10x96-Strip-Wells
EUR 6725

Sheep Scl-70 Antibody ELISA Kit

MBS035116-48StripWells 48-Strip-Wells
EUR 550

Sheep Scl-70 Antibody ELISA Kit

MBS035116-5x96StripWells 5x96-Strip-Wells
EUR 3420

Sheep Scl-70 Antibody ELISA Kit

MBS035116-96StripWells 96-Strip-Wells
EUR 765

Mouse Scl-70 Antibody ELISA Kit

MBS035621-10x96StripWells 10x96-Strip-Wells
EUR 6725

Mouse Scl-70 Antibody ELISA Kit

MBS035621-48StripWells 48-Strip-Wells
EUR 550

Mouse Scl-70 Antibody ELISA Kit

MBS035621-5x96StripWells 5x96-Strip-Wells
EUR 3420

Mouse Scl-70 Antibody ELISA Kit

MBS035621-96StripWells 96-Strip-Wells
EUR 765

Goose Scl-70 Antibody ELISA Kit

MBS033457-INQUIRE INQUIRE Ask for price

Camel Scl-70 Antibody ELISA Kit

MBS077184-INQUIRE INQUIRE Ask for price

Horse Scl-70 Antibody ELISA Kit

MBS043959-10x96StripWells 10x96-Strip-Wells
EUR 6725

Horse Scl-70 Antibody ELISA Kit

MBS043959-48StripWells 48-Strip-Wells
EUR 550

Horse Scl-70 Antibody ELISA Kit

MBS043959-5x96StripWells 5x96-Strip-Wells
EUR 3420

Horse Scl-70 Antibody ELISA Kit

MBS043959-96StripWells 96-Strip-Wells
EUR 765

Mouse Scl-70 Antibody ELISA Kit

MBS726620-10x96StripWells 10x96-Strip-Wells
EUR 5685

Mouse Scl-70 Antibody ELISA Kit

MBS726620-48StripWells 48-Strip-Wells
EUR 485

Mouse Scl-70 Antibody ELISA Kit

MBS726620-5x96StripWells 5x96-Strip-Wells
EUR 3020

Mouse Scl-70 Antibody ELISA Kit

MBS726620-96StripWells 96-Strip-Wells
EUR 690

Human Scl-70 Antibody ELISA Kit

MBS731454-10x96StripWells 10x96-Strip-Wells
EUR 5685

Human Scl-70 Antibody ELISA Kit

MBS731454-48StripWells 48-Strip-Wells
EUR 485

Human Scl-70 Antibody ELISA Kit

MBS731454-5x96StripWells 5x96-Strip-Wells
EUR 3020

Human Scl-70 Antibody ELISA Kit

MBS731454-96StripWells 96-Strip-Wells
EUR 690

Sheep Scl-70 Antibody ELISA Kit

MBS749914-10x96StripWells 10x96-Strip-Wells
EUR 5685

Sheep Scl-70 Antibody ELISA Kit

MBS749914-48StripWells 48-Strip-Wells
EUR 485

Sheep Scl-70 Antibody ELISA Kit

MBS749914-5x96StripWells 5x96-Strip-Wells
EUR 3020

Sheep Scl-70 Antibody ELISA Kit

MBS749914-96StripWells 96-Strip-Wells
EUR 690

Donkey Scl-70 Antibody ELISA Kit

MBS091123-INQUIRE INQUIRE Ask for price

Pigeon Scl-70 Antibody ELISA Kit

MBS058163-INQUIRE INQUIRE Ask for price

Bovine Scl-70 Antibody ELISA Kit

MBS021028-10x96StripWells 10x96-Strip-Wells
EUR 6725

Bovine Scl-70 Antibody ELISA Kit

MBS021028-48StripWells 48-Strip-Wells
EUR 550

Bovine Scl-70 Antibody ELISA Kit

MBS021028-5x96StripWells 5x96-Strip-Wells
EUR 3420

Bovine Scl-70 Antibody ELISA Kit

MBS021028-96StripWells 96-Strip-Wells
EUR 765

Canine Scl-70 Antibody ELISA Kit

MBS019498-10x96StripWells 10x96-Strip-Wells
EUR 6725

Canine Scl-70 Antibody ELISA Kit

MBS019498-48StripWells 48-Strip-Wells
EUR 550

Canine Scl-70 Antibody ELISA Kit

MBS019498-5x96StripWells 5x96-Strip-Wells
EUR 3420

Canine Scl-70 Antibody ELISA Kit

MBS019498-96StripWells 96-Strip-Wells
EUR 765

Rabbit Scl-70 Antibody ELISA Kit

MBS030653-INQUIRE INQUIRE Ask for price

Monkey Scl-70 Antibody ELISA Kit

MBS042947-10x96StripWells 10x96-Strip-Wells
EUR 6725

Most cancers/Testis Antigens: from Serology to mRNA Most cancers Vaccine 

Most cancers/testis antigens (CTAs) are a gaggle of tumor antigens expressed in quite a few most cancers tissues, in addition to within the testis and placental tissues. There are over 200 CTAs supported by serology and expression information. The expression patterns of CTAs replicate the similarities between the processes of gametogenesis and tumorigenesis. It’s notable that CTAs are extremely expressed in three kinds of cancers (lung most cancers, bladder most cancers, and pores and skin most cancers), all of which have a metallic etiology.

Right here, we assessment the expression, regulation, and performance of CTAs and their translational prospects as most cancers biomarkers and remedy targets. Many CTAs are extremely immunogenic, tissue-specific, and regularly expressed in most cancers tissues however not underneath physiological circumstances, rendering them promising candidates for most cancers detection. Some CTAs are related to medical outcomes, so they might function prognostic biomarkers. A small variety of CTAs are membrane-bound, making them very best targets for chimeric antigen receptor (CAR) T cells. Mounting proof means that CTAs induce humoral or mobile immune responses, offering most cancers immunotherapeutic alternatives for T-cell receptors (TCRs), CAR T cell, antibody-primarily based remedy and peptide- or mRNA-based vaccines. Certainly, CTAs are the dominating non-mutated targets in mRNA most cancers vaccine growth.

Medical trials on CTA TCR and vaccines have proven effectiveness, security, and tolerance, however these successes are restricted to a small variety of sufferers. In-depth research on CTA expression and performance are wanted to enhance CTA-based immunotherapy.

Chimeric Antigen Receptor T Cell Remedy: A Complete Overview of Medical Efficacy, Toxicity, and Greatest Practices for Outpatient Administration 

Chimeric antigen receptor T cell (CAR-T) remedy has been built-in into remedy algorithms for acute leukemia and lymphoma, and the variety of medical trials in each hematologic and stable tumor malignancies for brand spanking new merchandise and potential indications continues to develop. The medical toxicities of CAR-T remedy embrace cytokine launch syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS), which usually warrant inpatient admission for shut monitoring and remedy. Consequently, many facilities have constructed processes round administration of those cells within the inpatient setting. As new merchandise achieve Meals and Drug Administration approval with extra manageable toxicity profiles, and as establishments achieve expertise with the administration of those toxicities, outpatient administration and monitoring must be anticipated.

As well as, payer reimbursements for inpatient remedy have left the sustainability of inpatient CAR-T remedy in jeopardy, particularly for facilities whose payer combine features a excessive proportion of Medicare sufferers. This has the intense potential to restrict entry to care. As use of CAR-T remedy continues to develop, adjustments in fee fashions, care settings, or each are wanted to make sure the sustainability of secure, environment friendly, and cost-effective remedy. This assessment outlines the efficacy and toxicity of at the moment accredited merchandise in addition to greatest practices to optimize the administration of CAR-T remedy within the outpatient setting.

IFCC interim tips on fast point-of-care antigen testing for SARS-CoV-2 detection in asymptomatic and symptomatic people 

With an virtually unremittent development of extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections all world wide, there’s a compelling must introduce fast, dependable, and high-throughput testing to permit acceptable medical administration and/or well timed isolation of contaminated people. Though nucleic acid amplification testing (NAAT) stays the gold customary for detecting and theoretically quantifying SARS-CoV-2 mRNA in numerous specimen sorts, antigen assays could also be thought-about an acceptable various, underneath particular circumstances.

Speedy antigen checks are supposed to detect viral antigen proteins in organic specimens (e.g. nasal, nasopharyngeal, saliva), to point present SARS-CoV-2 an infection. The obtainable assay methodology contains fast chromatographic immunoassays, used on the point-of-care, which carries some benefits and disadvantages in comparison with extra standard, instrumentation-based, laboratory immunoassays.

Due to this fact, this doc by the Worldwide Federation for Medical Chemistry and Laboratory Medication (IFCC) Taskforce on COVID-19 goals to summarize obtainable information on the efficiency of at the moment obtainable SARS-CoV-2 antigen fast detection checks (Ag-RDTs), offering interim steering on medical indications and goal populations, assay choice, and analysis, check interpretation and limitations, in addition to on pre-analytical concerns. This doc is therefore primarily aimed to help laboratory and controlled well being professionals in choosing, validating, and implementing regulatory accredited Ag-RDTs.

Chemotherapy brokers stimulate dendritic cells towards human colon most cancers cells by upregulation of the transporter related to antigen processing 

Single immunotherapy fails to reveal efficacy in sufferers with microsatellite steady (MSS) metastatic colorectal most cancers (mCRC). Analysis on immune reactions earlier than and after systemic brokers for mCRC is warranted. Our research examined cell line fashions to match the expression of immune floor markers on colon most cancers cells earlier than and after chemotherapy brokers. We additionally elucidated mechanisms underlying the results of chemotherapy brokers on immune floor markers. We used real-world medical samples with NanoString evaluation and the Perkin-Elmer Opal multiplex system. We established that chemotherapy brokers, notably 7-ethyl-10-hydroxycamptothecin (SN-38), the energetic metabolite of irinotecan, stimulated the expression of stimulatory MHC class I alleles by stimulation the pathway of transporters related to antigen processing 1 and a couple of (TAP1 and TAP2) in cell line fashions.

Utility of contaminated cell protein 47 (ICP-47), a selected inhibitor of the TAP1/TAP2, considerably inhibited expression of TAP1/TAP2 and likewise inhibited the expression of the downstream MHC class I. Within the practical assay, SN-38 considerably promoted the phagocytosis of colon most cancers cells by monocyte-derived dendritic cells (MoDCs). We confirmed that the expression of main histocompatibility complicated (MHC) class I, considerably elevated after first-line chemotherapy and focused remedy within the samples of real-world sufferers with de novo mCRC. Our research supplies new insights for novel immunotherapy mixtures.

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